The renal clearance of hydrochlorothiazide in patients with regular renal perform is 285mL/min. Individuals having a creatinine clearance of 31-80mL/min have a median hydroxychlorothiazide renal clearance of 75mL/min, and individuals using a creatinine clearance of ≤30mL/min have a median hydroxychlorothiazide renal clearance of 17mL/min.

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Symptoms of overdose contain hypotension and tachycardia or bradycardia. Terlipressin could possibly be specified to take care of hypotension and tachycardia if common vasopressors are unsuccessful to manage blood pressure.

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